History of anastrozole and its benefits over other popular aromatase inhibitors

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Anastrozole is an antiestrogenic drug developed to treat advanced breast cancer in women. Anastrozole is the first in the class of third generation aromatase inhibitors. Anastrozole reversibly binds aromatase by competitive inhibition; it inhibits the conversion of androgens to estrogens in peripheral tissues.

Anastrozole has a significant effect on estrogen levels, and one daily dose of 1 mg (1 tablet) suppresses estrogen in more than 80% of patients.

Also, anastrozole bodybuilding use is very common to control hormonal processes.

The history of anastrozole

Anastrozole was developed by Zeneca Pharmaceuticals and in late 1995 was approved for use in the United States. The drug was developed as a new treatment for the treatment of resectable breast cancer in women. It has become an alternative to Tamoxifen. In the course of comparative tests, a significant advantage of Anastrozole over Tamoxifen was revealed. As a result of treatment, patients showed regression of the disease and improved overall survival rates. Since about 2002, the drug has also become popular with men (bodybuilders and athletes), as it causes strong estrogen suppression and allows steroids to be taken without risks.

Why Anastrozole Became Popular With Athletes

Anastrozole and the drug Arimidex based on it at some point became the most popular means against increased production of estrogen and suppression of testosterone while taking anabolic steroids. There is a specific reason for this change.

Prior to its introduction, Nolvadex and Proviron were the main tools against estrogen. Combined with each other, they were very effective. But Arimidex does the same job more efficiently. Its use is becoming more and more popular. The same as in the clinic, a dose of one tablet, and for some even half a tablet every day, brings an exceptional effect. When heavily flavored drugs are used, side effects such as gynecomastia and water retention are easily blocked. In combination with proscar (finasteride), the side effects associated with the use of highly aromatized drug bundles can be minimized. At the same time, the quality of the muscles will improve, as excess water will drain.

Side effects and limitations of taking anastrozole

Anastrozole has certain negative aspects and limitations to its use. Common side effects (common to all aromatase inhibitors) are joint pain, weakness, fatigue, mood swings, depression, high blood pressure, swelling of the arms / legs, and headache. Aromatase inhibitors can also lead to a decrease in bone mineral density, which can trigger the development of osteoporosis and increase the number of fractures in susceptible patients.

Some people may also experience side effects such as gastrointestinal problems, nausea and vomiting. When taken in men to lower estrogen levels for extended periods of therapy, aromatase inhibitors may increase the risk of developing cardiovascular disease (CVD). The point is that estrogen is important in the body. It has a positive effect on cholesterol. Anastrozole has a strong effect on estrogen production, and people with heart problems can pose an additional threat. This is not a complete limitation for athletes as they can use other aromatase inhibitors in such cases.


Anastrozole uses against estrogen is the most effective in its class at the moment for bodybuilders. It has certain limitations to its use, but its strong effect on most athletes has made it widely popular for the last almost 20 years, and it is a drug to look out for if the task is to block estrogen from taking steroids.